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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 497-508 doi: 10.1007/s11684-017-0572-1
Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
关键词: genome-editing tools tumorigenic virus delivery method off-target effect virus-related carcinoma
Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU
《能源前沿(英文)》 2016年 第10卷 第1期 页码 57-64 doi: 10.1007/s11708-015-0385-3
关键词: steam turbine rotor thermal stress heat transfer coefficient empirical formula
Advanced purification and comprehensive utilization of yellow phosphorous off gas
Ping NING,Xiangyu WANG
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 181-189 doi: 10.1007/s11783-014-0698-1
关键词: yellow phosphorous off gas purification comprehensive utilization
Typical off-design analytical performances of internal combustion engine cogeneration
Xiaohong HE, Ruixian CAI
《能源前沿(英文)》 2009年 第3卷 第2期 页码 184-192 doi: 10.1007/s11708-009-0007-z
关键词: internal combustion engine (ICE) cogeneration heat recovery steam generator (HRSG) off-design superheated steam saturated steam ambient pressure
《环境科学与工程前沿(英文)》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1455-x
• Emissions from 53 in-use diesel-fueled off-road equipment were measured.
关键词: Off-road equipment Portable emission measurement system (PEMS) Real-world emissions Diesel engine
Construction Technology of Off-Site Precast Concrete Buildings
Ting Gong,Jian Yang,Hao Hu,Feng Xu
《工程管理前沿(英文)》 2015年 第2卷 第2期 页码 122-124 doi: 10.15302/J-FEM-2015039
关键词: off-site construction precast concrete modular construction construction management building information model (BIM)
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
《工程管理前沿(英文)》 2017年 第4卷 第2期 页码 111-126 doi: 10.15302/J-FEM-2017027
关键词: on-site maintenance petrochemical industry safety off-site maintenance system
Jian LU,Paul S. WILLS,P. CHRIS WILSON
《环境科学与工程前沿(英文)》 2016年 第10卷 第3期 页码 477-481 doi: 10.1007/s11783-015-0820-z
关键词: off-flavor/odor compounds liquid-liquid microextraction gas chromatography-tandem mass spectrometry
Can energy storage make off-grid photovoltaic hydrogen production system more economical?
《工程管理前沿(英文)》 页码 672-694 doi: 10.1007/s42524-022-0245-x
关键词: hydrogen off-grid photovoltaic energy storage LCOH engineering economics
Multi-target combinatory strategy to overcome tumor immune escape
《医学前沿(英文)》 2022年 第16卷 第2期 页码 208-215 doi: 10.1007/s11684-022-0922-5
关键词: immune checkpoints multi-target immune escape immune-related adverse events combination therapy
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP
《能源前沿(英文)》 2015年 第9卷 第2期 页码 231-237 doi: 10.1007/s11708-015-0358-6
关键词: non-intrusive appliance load monitoring event detection goodness-of-fit (GOF) K-means clustering ON-OFF pairing
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 52-60 doi: 10.1007/s11684-016-0433-3
Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
关键词: PPM1D hepatocellular carcinoma prognosis target therapy
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
《信息与电子工程前沿(英文)》 2015年 第16卷 第11期 页码 985-994 doi: 10.1631/FITEE.1500149
关键词: Maneuvering target tracking Prolonged smooth regions Variable rate model Maneuver detection
Dan WU, Chunyan ZHANG, Li HAO, Changjun GENG, Xie QUAN,
《环境科学与工程前沿(英文)》 2009年 第3卷 第4期 页码 483-491 doi: 10.1007/s11783-009-0144-y
关键词: biodegradation volatile organic compounds (VOCs) biofiltration biofilter
标题 作者 时间 类型 操作
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
期刊论文
Effect of heat transfer coefficient of steam turbine rotor on thermal stress field under off-design condition
Jie GUO,Danmei XIE,Hengliang ZHANG,Wei JIANG,Yan ZHOU
期刊论文
Advanced purification and comprehensive utilization of yellow phosphorous off gas
Ping NING,Xiangyu WANG
期刊论文
Typical off-design analytical performances of internal combustion engine cogeneration
Xiaohong HE, Ruixian CAI
期刊论文
Quantification of emission variability for off-road equipment in China based on real-world measurements
期刊论文
Construction Technology of Off-Site Precast Concrete Buildings
Ting Gong,Jian Yang,Hao Hu,Feng Xu
期刊论文
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
期刊论文
Trace analysis of off-flavor/odor compounds in water using liquid-liquid microextraction coupled with
Jian LU,Paul S. WILLS,P. CHRIS WILSON
期刊论文
A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load
Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP
期刊论文
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
null
期刊论文
Amodified variable rate particle filter for maneuvering target tracking
Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU
期刊论文